A flower-like hybrid material composed of Fe3O4, graphene oxide and CdSe nanodots for magnetic solid phase extraction of ibuprofen prior to its quantification by HPLC detection

A flower-like Fe3O4/GO/CdSe nanodot magnetic hybrid material was produced and applied to magnetic solid-phase extraction of ibuprofen from pharmaceuticals, water, and urine samples. The material was characterized by X-ray diffraction, Raman spectroscopy and field emission scanning electron microscopy and SEM-EDX. The pH value, volume of sample solution, amount of sorbent, type and volume of elution solvent and extraction time were optimized. Following elution with acetone, ibuprofen was quantified by HPLC-DAD detection. The recoveries of ibuprofen from spiked real samples ranged between 87 and 109%, and the intra-day and inter-day relative standard deviations from 1.25 to 3.02%. The limit of detection, limit of quantification and preconcentration factor are 0.36 ng.mL(-1),1.20 ng.mL(-1) and 150, respectively.