Evaluation of the quality consistency of Zhenju Jiangya Tablets by systematic quantified fingerprint method in combination with antioxidant activity and three compounds analyses

Zhenju Jiangya tablets (ZHJYP) are widely used as antihypertensive medicine. In this study we aimed to establish a comprehensive analytical method to evaluate the overall quality of ZHJYP. The fingerprints of ZHJYP were established by high performance liquid chromatography (HPLC) and then multi-wavelength fusion fingerprints were generated. Meanwhile quantitative analysis of three active ingredients was also carried out. The systematic quantified fingerprint method (SQFM) was used to analyze the similarity of fingerprint in qualitative and quantitative aspects. The evaluation results showed that all the samples were well differentiated and classified into different grades. Furthermore, the fingerprint-efficacy relationship between fingerprint and antioxidant activity was also studied by partial least-squares model. The method established in this paper can provide a scientific and promising reference for the QC of ZHJYP and other similar herbal preparations.