Journal
MEDICINE
Volume 98, Issue 44, Pages -Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MD.0000000000017781
Keywords
Helicobacter pylori; meta-analysis; nonalcoholic fatty liver
Categories
Funding
- National Natural Science Foundation of China [81660158, 81460092, 81400372]
- Natural Science Key Project of Jiangxi Province [20161ACB21017]
- Key Research Foundation of Jiangxi Province [20151BBG70223, 20181BBG70004]
- Youth Science Foundation of Jiangxi Province [20151BAB215016, 20161BAB215198]
- Education Department Key Project of Jiangxi Province [GJJ160020]
- Teaching Reform of Degree and Graduate Education Research Project of Jiangxi Province [JXYJG-2018-013]
- Grassroots Health Appropriate Technology Spark Promotion Plan Project of Jiangxi Province [20188003]
- Health Development Planning Commission Science Foundation of Jiangxi Province [20175116]
- Health Development Planning Commission Science TCM Foundation of Jiangxi Province [20150823]
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Background: Opinion regarding whether Helicobacter pylori infection can promote the occurrence and development of nonalcoholic fatty liver (NAFLD) is divided. Therefore, we aimed to assess the exact relationship between H pylori infection and NAFLD by integrating all available data. Methods: The articles about H pylori infection and NAFLD were collected by searching the databases of PubMed, Embase, Web of Science, Scopus, China National Knowledge Infrastructure, and WanFang. The random-effects model was used for data analysis, followed by subgroup analysis and meta-regression to explore sources of heterogeneity. Results: Twenty-one articles were included in the study. Pooled analysis showed that H pylori infection indeed promoted NAFLD. Subgroup analysis and regression analysis showed that case-control ratio may be one of the sources of heterogeneity. Conclusions: H pylori infection is indeed one of the factors that promotes the progression of NAFLD for the Asian population. This provides new approaches for clinical prevention and treatment for NAFLD.
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