Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 104, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.msec.2019.110001
Keywords
Electrohydrodynamic co-jetting; Janus particles; Multifunctional drug delivery system; Anti-cancer
Categories
Funding
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- National Natural Science Foundation of China [51773093, 11204033]
- Natural Science Foundation of Jiangsu Province [BK20141397]
- Postgraduate Research & Practice Innovation Program of Jiangsu Province [SJCX17_0118]
- Fundamental Research Funds for the Central Universities [30916011313]
- Open Research Fund of State Key Laboratory of Bioelectronics, Southeast University
- NSF [1806138, 1825122, 1607475, 1510099]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1607475] Funding Source: National Science Foundation
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1510099] Funding Source: National Science Foundation
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Paclitaxel is broad-spectrum anticancer drug which has been widely used in clinic. However, traditional drug delivery often suffers from the scarcity of resources and systemic toxic side effects caused by the localization to non-tumor areas, rendering cancer treatment extremely challenging. To address this problem, we developed a novel multifunctional drug delivery system of a poly(lactic-co-glycolic acid) (PLGA) drug-loaded magnetic Janus particles (DMJPs) using electrohydrodynamic (EDH) co-jetting. The DMJPs were loaded with three compartments each with distinct function, Le. paclitaxel for killing cancer cell, Fe3O4 nanoparticles for target location, and rhodamine B for fluorescence tracing, respectively. The Janus structure of the DMJPs, as demonstrated by the loaded nano-quantum dots CdS/ZnS and CdSe/ZnS in different compartments, enhanced not only the drug loading and encapsulation efficiency but also the cumulative release rate of the loaded drugs from DMJPs in different media. More importantly, DMJPs exhibited specific and high toxicity only to human breast cancer cells (MDA-MB-231), but not to mouse embryonic fibroblasts (NIH-3 T3). Consistently, DMJPs induced the higher lethal effect on cancer cells than paclitaxel suspension of high concentrations. Under guidance of external magnetic field, DMJPs can readily target and accumulate on and inside cancer cells for cell elimination. The specific targetability, selectivity, and toxicity of DMJPs on cancer cells would greatly avoid any potential side effects and reduce the overdose of drugs for conventional drug delivery. This work hopefully provides a new drug delivery system for the development of anticancer drug systems for clinical and precision medicine treatment.
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