Journal
MACROMOLECULAR BIOSCIENCE
Volume 19, Issue 12, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201900255
Keywords
anti-infection; anti-inflammation; multi-functional; osteoblast calcification; silicon carrier
Funding
- National Natural Science Foundation of China [51773198, 51673188]
- Jilin Provincial Science and Technology Department [20170101091JC]
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Implant materials applied in bone defect commonly focus on the inducement of bone regeneration and neglect to cure complications including bacterial infection and inflammation, which may result in delayed unions or even amputation. In this study, a microporous silica nanoparticle-poly(N-isopropylacrylamide-b-(2-(dimethylamino)ethyl methacrylate) is synthesized for loading DXMS and the ECM-derived peptide (Sequence: Succinic acid-GTPGPQGIAGQRGVV) in order to enhance the osteoblast calcification and relieve related symptoms. Positively charged PDMA blocks endow the nanoparticle with the antimicrobial property. Moreover, the combination of DXMS makes it have the ability of anti-inflammation and promoting calcification formation. Furthermore, incorporation of the peptide leads to a significant improvement of mineralization and alkaline phosphatase expression in the preosteoblast. After intramuscular implantation in mice for four weeks, the results indicate the composite nanoparticle can promote ectopic bone formation. These combined properties make the composite silicon nanoparticle a promising osteogenic drug appropriate for further study in bone repair and related combination therapy.
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