Journal
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
Volume 74, Issue 14, Pages 1823-1838Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacc.2019.08.1017
Keywords
acute coronary syndromes; calcification; chronic kidney disease; coronary artery disease; revascularization
Categories
Funding
- Kidney Disease: Improving Global Outcomes
- Akebia Therapeutics
- Amgen
- Fresenius Medical Care
- Kyowa Kirin
- Abbott Vascular
- Pfizer
- Reata
- Boston Scientific
- Medtronic
- Siemens
- Novo Nordisk
- National Institutes of Health (NIH)
- Medicines Company
- Sanofi
- Roche Diagnostics
- Ortho Clinical Diagnostics
- Amylin and Boehringer Ingelheim
- AbbVie
- OxThera
- Bristol-Myers Squibb
- National Institute of Diabetes and Digestive and Kidney Diseases/NIH
- National Heart, Lung, and Blood Institute/NIH
- AstraZeneca
- Napp/Mundipharma
- Vifor Fresenius Medical Care Renal Pharma
- Mitsubishi Tanabe
- Pharmacosmos
- Daichii-Sankyo
- GE Medical Systems
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Chronic kidney disease (CKD) is a major risk factor for coronary artery disease (CAD). As well as their high prevalence of traditional CAD risk factors, such as diabetes and hypertension, persons with CKD are also exposed to other nontraditional, uremia-related cardiovascular disease risk factors, including inflammation, oxidative stress, and abnormal calcium-phosphorus metabolism. CKD and end-stage kidney disease not only increase the risk of CAD, but they also modify its clinical presentation and cardinal symptoms. Management of CAD is complicated in CKD patients, due to their likelihood of comorbid conditions and potential for side effects during interventions. This summary of the Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference on CAD and CKD (including end-stage kidney disease and transplant recipients) seeks to improve understanding of the epidemiology, pathophysiology, diagnosis, and treatment of CAD in CKD and to identify knowledge gaps, areas of controversy, and priorities for research. (C) Published by Elsevier on behalf of the American College of Cardiology Foundation.
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