Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 141, Issue 49, Pages 19263-19268Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b11298
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Funding
- JSPS Kakenhi [JP17H06450, JP26220803, JP18H01975]
- Japan Society for the Promotion of Science (JSPS)
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Optically active sulfoximines are a promising substance in medicinal chemistry. However, a methodology for preparing chiral sulfoximines in a stereoselective manner has been underdeveloped. Here, we report an asymmetric synthesis of chiral sulfoximines having an aryl group by the newly developed sulfur-selective arylation of easily accessible chiral sulfinamides. The utility of the present method is demonstrated by the asymmetric synthesis of a key intermediate of a COX-2 inhibitor.
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