Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 141, Issue 41, Pages 16249-16254Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b09245
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Funding
- Yale University
- Amgen
- Sloan Foundation
- Bristol-Myers Squibb Graduate Research Fellowship
- Dox Fellowship
- Marco Polo Program
- Swiss National Science Foundation
- Anderson Postdoctoral Fellowship
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This report demonstrates the possibility of a nickel-catalyzed difunctionalization of unactivated alkenes initiated by an unstabilized enolate nucleophile. The process tolerates a diverse range of electrophiles, including aryl, heteroaryl, alkenyl, and amino electrophiles. An electron-deficient phosphine ligand and a tetrabutylammonium salt additive were crucial for promoting efficient vicinal difunctionalization.
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