Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 141, Issue 41, Pages 16288-16295Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b05688
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Funding
- SNSF [200020_169141]
- NCCR Chemical Biology
- Swiss National Science Foundation (SNF) [200020_169141] Funding Source: Swiss National Science Foundation (SNF)
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DNA-based circuitry empowers logic gated operations and amplifications but is restricted to nucleic acid output. Templated reactions enable the translation of nucleic acid cues into diverse small-molecule outputs but are more limited in their amplification. Herein, we demonstrate the coupling of a DNA circuit to templated reactions in order to achieve high levels of amplification in the output of small molecules, in response to nucleic acid input. We demonstrate that the coupling of the DNA circuit to templated reactions allows for the detection of the fM concentration of analyte and can respond with the release of a cytotoxic drug.
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