Journal
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
Volume 199, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jphotobiol.2019.111623
Keywords
Circannual rhythms; Cultivar system; Microbial metabolites; Organic grapes; Phase II metabolites; Seasonal fruits
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Funding
- Spanish Ministry of Economy and Competitiveness [AGL2013-49500-EXP, AGL201677105-R, RTC-2017-6044-2]
- European Regional Development Funds of the European Union within the Operative Program FEDER of Catalunya
- Universitat Rovira i Virgili Marti i Franques [2015PMF-PIPF-50]
- Universitat Rovira i Virgili -Marti i Franques [2015PMF-PIPF-51, URV-LE-621, URV-AG-587]
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The consumption of grapes, rich in polyphenols, have several health effects. These effects are mainly attributed to the polyphenol metabolites generated after their ingestion. Several factors that affects host's physiology can modulate the bioavailability of grape polyphenols and, in turn, their effects. Mammals undergo physiological and metabolic changes due to the different day length (photoperiod) within a year. Thus, the aim of this study is to investigate if the bioavailability of phenolic compounds from the same red grapes with a different polyphenol profile (i.e. red grape produced organically (OG) or non-organically (conventional, CG)) differs with the photoperiod exposure. For this, the serum phenolic metabolites of Fischer 344 rats keep at different photoperiods (18, 12 or 6 h of light per day) and administered with OG or CG for 10-week were profiled by HPLC-MS/MS. Our results indicated that rats administered with OG reported a higher total serum metabolite concentration independent of the photoperiod exposure and CG-administered rats showed a more varied serum metabolite profile depending of the photoperiod exposure. Those rats exposed to 6 h of light per day, which emulates winter light conditions, presented a higher bioavailability of grape phenolics. Therefore, grape cultivar and animal photoperiod exposure condition grape phenolics' bioavailability.
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