Journal
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
Volume 42, Issue 8, Pages E756-E758Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MPH.0000000000001647
Keywords
hemophagocytic lymphohistiocytosis; Epstein-Barr virus; Epstein-Barr virus– encoded small RNA; cytologic diagnosis
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Funding
- Japan Society for the Promotion of Science (JSPS) [17K10095]
- Grants-in-Aid for Scientific Research [17K10095] Funding Source: KAKEN
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A 3-year-old boy was clinically diagnosed with Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis. We identified EBV-infected CD8-positive T-lymphocytes by cytologic double staining of the peripheral blood for EBV-encoded small RNA and cell surface markers. The patient was subsequently administered immunosuppressive therapy with a reduced dose of etoposide because of previous organ damage. EBV clearance was confirmed by serial quantification of cell-fractionated EBV-DNA, whereas EBV-DNA persisted in the plasma for 18 weeks. Immunochemotherapy with low-dose etoposide combined with serial viral load monitoring is a potential therapeutic option for severe EBV-hemophagocytic lymphohistiocytosis cases with organ damage.
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