Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 84, Issue 23, Pages 15735-15744Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.9b02411
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Funding
- CSIR-IICT [EMR/2017/001266]
- SERB, DST New Delhi, India [EMR/2017/001266]
- Council of Scientific and Industrial Research (CSIR), New Delhi
- DST-INSPIRE, New Delhi, India
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The enantioselective desymmetrization via remote C(sp(2))-H amidation of the prochiral 2,2-disubstituted cyclopentene-1,3-dione with N-methoxybenzamide has been developed. The overall process was catalyzed by a chiral bifunctional thiourea catalyst through a sequential conjugate-addition-elimination-tautomerization. This strategy provides rapid access to highly functionalized five-membered carbocycles, bearing an all-carbon quaternary stereogenic center through remote stereocontrol in high yields with moderate to excellent enantioselectivities.
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