Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 84, Issue 22, Pages 14627-14635Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.9b02211
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Funding
- China Postdoctoral Science Foundation [2017M621972]
- Zhejiang Post-Doctoral Preferential Fund Project [zj20180084]
- Natural Science Foundation of Zhejiang Province [LQ19B020001]
- Science and Technology Plan Project of Taizhou [1803gy04]
- Project of Taizhou University Fund for Excellent Young Scholars
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The first transition-metal-free catalytic protocol for controlled reduction of amide functions using cheap and bench-stable hydrosilanes as reducing agents has been established. By altering the hydrosilane and solvent, the new method enables the selective cleavage of unactivated C-O bonds in amides and allows the C-N bonds to selectively break via the deacylated cleavage. Overall, this novel process may offer a versatile alternative to current methodologies employing stoichiometric metal systems for the controlled reduction of carboxamides.
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