Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 84, Issue 21, Pages 13252-13261Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.9b00821
Keywords
-
Categories
Funding
- Natural Sciences and Engineering Research Council of Canada
- University of Western Ontario
Ask authors/readers for more resources
A selection of benzyl-based protecting groups for thiouracil (U-s) for the synthesis of pseudo-complementary peptide nucleic acid (PNA) has been evaluated. The 4-methoxybenzyl-protecting group that has found use for s U during Boc-based oligomerization is also suitable for Fmoc-based oligomerization. Furthermore, it is demonstrated that U-s protection is unnecessary for the successful synthesis of thiouracil-containing PNA. The new 2-thiothymine (T-s) PNA monomer has also been prepared and incorporated into an oligomer and its binding to complementary PNA evaluated.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available