Journal
JOURNAL OF NUCLEAR MEDICINE
Volume 60, Issue 12, Pages 1691-1697Publisher
SOC NUCLEAR MEDICINE INC
DOI: 10.2967/jnumed.118.225169
Keywords
P-selectin; molecular imaging; inflammation; inflammatory imaging biomarker
Funding
- NIH [T32 HL129964]
- Pittsburgh Foundation
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P-selectin is an adhesion molecule translocated to the surface of endothelial cells and platelets under inflammatory stimuli, and its potential as a biomarker in inflammatory conditions has driven preclinical studies to investigate its application for molecular imaging of inflammation. Clinical imaging of P-selectin expression for disease characterization could have an important role in stratifying patients and determining treatment strategies. The objective of this review is to outline the role of P-selectin in cardiovascular inflammatory conditions and its translation as an early inflammatory biomarker for several molecular imaging modalities for diagnostic purposes and therapeutic planning.
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