Journal
JOURNAL OF NEUROSCIENCE
Volume 39, Issue 50, Pages 10019-10033Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1642-19.2019
Keywords
adaptation; auditory cortex; neural coding; somatosensory cortex; visual cortex
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Funding
- Human Frontiers Science Program
- Washington Research Foundation, University of Washington Institute of Neuroengineering
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Sensory systems encounter remarkably diverse stimuli in the external environment. Natural stimuli exhibit timescales and amplitudes of variation that span a wide range. Mechanisms of adaptation, a ubiquitous feature of sensory systems, allow for the accommodation of this range of scales. Are there common rules of adaptation across different sensory modalities? We measured the membrane potential responses of individual neurons in the visual, somatosensory, and auditory cortices of male and female mice to discrete, punctate stimuli delivered at a wide range of fixed and nonfixed frequencies. We find that the adaptive profile of the response is largely preserved across these three areas, exhibiting attenuation and responses to the cessation of stimulation, which are signatures of response to changes in stimulus statistics. We demonstrate that these adaptive responses can emerge from a simple model based on the integration of fixed filters operating over multiple time scales.
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