Journal
JOURNAL OF NEUROSCIENCE
Volume 39, Issue 46, Pages 9107-9118Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0419-19.2019
Keywords
axon regeneration; c-Myc; optic nerve regeneration; p53; telomerase reverse transcriptase
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Funding
- National Natural Science Foundation of China [81772353, 81571189]
- National Key Research and Development Program [2016YFC 1100203]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Innovation and Entrepreneurship Program of Jiangsu Province
- NIH [R01NS064288, R01NS085176, R01GM111514, R01EY027347]
- Craig H. Neilsen Foundation
- BrightFocus Foundation
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Although several genes have been identified to promote axon regeneration in the CNS, our understanding of the molecular mechanisms by which mammalian axon regeneration is regulated is still limited and fragmented. Here by using female mouse sensory axon and optic nerve regeneration as model systems, we reveal an unexpected role of telomerase reverse transcriptase (TERT) in regulation of axon regeneration. We also provide evidence that TERT and p53 act downstream of c-Myc to control sensory axon regeneration. More importantly, overexpression of p53 in sensory neurons and retinal ganglion cells is sufficient to promote sensory axon and optic never regeneration, respectively. The study reveals a novel c-Myc-TERT-p53 signaling pathway, expanding horizons for novel approaches promoting CNS axon regeneration.
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