Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 335, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2019.577007
Keywords
Multiple sclerosis; Central nervous system; Neurodegenerative; Nutraceutical
Categories
Funding
- FAPERGS [16/2551-0000526-5, 16/2251-0000183-9]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior -Brasil (CAPES) [001]
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We investigated the effects of chrysin in the experimental autoimmune encephomyelitis (EAE), a multiple sclerosis (MS) animal model. EAE was induced using myelin oligodendrocyte glycoprotein (MOG) 35-55 peptide in C57BL/6 mice. Chrysin reduced weight loss, attenuated clinical signs and blunted the EAE-induced increase in histone deacetylase (HDCA) activity, glycogen synthase kinase-3 beta (GSK-3 beta) levels and pro-inflammatory cytokine levels as well as in the EAE-induced decrease in histone acetyltransferases 3 and 4 (HAT3, HAT4). Altogether, results demonstrate beneficial effects and potential targets of chrysin in EAE.
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