Journal
JOURNAL OF NATURAL PRODUCTS
Volume 82, Issue 11, Pages 3083-3088Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.9b00690
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Funding
- Ministry of Science, ICT & Future Planning [NRF-201SM1A5A1037572]
- National Research Foundation of Korea (NRF)
- Center for Women In Science, Engineering and Technology (WISET) - Ministry of Science and ICT (MSIT) under the Program for Returners into RD
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Four new meroterpenoids, austalides V-X (1-3) and a farnesylated phthalide derivative (4), were isolated from the culture of the marine fungus Penicillium rudallense, together with eight known meroterpenoids derivatives (5-12). Their structures, including absolute configurations, were determined by spectroscopic methods. All of the isolated compounds were evaluated for their inhibitory activities on the receptor activator of nuclear factor kappa B ligand (RANKL)-induced osteoclast differentiation. Compounds 1, 2, 5-7, and 10 exhibited potent osteoclast differentiation inhibitory activity with ED50 values of 1.9-2.8 mu M.
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