Journal
JOURNAL OF NATURAL PRODUCTS
Volume 82, Issue 11, Pages 3201-3204Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.9b00905
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Funding
- National Natural Science Foundation of China [41830535, 41806194, 41706155, U1706210, U1606403]
- National Science and Technology Major Project for Significant New Drugs Development, China [2018ZX09735-004]
- Taishan Scholars Program, China
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A novel perylenequinone-related compound, alternatone A (1), with an unprecedented tricyclo[6.3.1.0(2,7)] dodecane skeleton, together with three known perylenequinones, altertoxin I (2), stemphyperylenol (3), and alterperylenol (4), was isolated from the soft-coral-derived fungus Alternaria alternata L3111'. Their structures including absolute configurations were elucidated on the basis of comprehensive spectroscopic analysis, electronic circular dichroism calculations, and X-ray diffraction data. Compound 4 showed cytotoxicity against A-549, HCT-116, and HeLa cell lines with IC50 values of 2.6, 2.4, and 3.1 mu M, respectively. A possible biosynthetic pathway of 1 was proposed.
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