Journal
JOURNAL OF NATURAL PRODUCTS
Volume 82, Issue 10, Pages 2800-2808Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.9b00481
Keywords
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Funding
- National Key R&D Program of China [2018YFC0311002]
- National Natural Science Foundation of China [81773587]
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The new streptoglutarimides A-J (1-10) and the known streptovitacin A (11) were isolated from a marine-derived actinomycete, Streptomyces sp. ZZ741. Structures of the isolated compounds were elucidated based on their HRESIMS data, extensive NMR spectroscopic analyses, ECD calculations, Mosher's method, and a single-crystal X-ray diffraction experiment. Streptoglutarimide H (8) and streptovitacin A (11) showed potent antiproliferative activity against human glioma U87MG and U251 cells with IC50 values of 1.5-3.8 mu M for 8 and 0.05-0.22 mu M for 11. All isolated compounds exhibited antimicrobial activity with MIC values of 9-11 mu g/mL against methicillin-resistant Staphylococcus aureus, 8-12 mu g/mL against Escherichia coli, and 8-20 mu g/mL against Candida albicans.
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