Journal
JOURNAL OF MOLECULAR LIQUIDS
Volume 293, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.molliq.2019.111513
Keywords
Chlorothalonil; Hydroxypropyl-beta-cyclodextrin; beta-Cyclodextrin; Inclusion complex
Funding
- National Natural Science Foundation of China [31801784, 31572042]
- Natural Science Foundation of Heilongjiang Province [ZD2017002]
- Heilongjiang Province Postdoctoral Science Foundation [LBH-Z16030]
- Research Science Foundation in Technology Innovation of Harbin [2017RAQXJ017]
- Academic Backbone Project of Northeast Agricultural University [16XG24]
- Heilongjiang Province Students' Innovation and Entrepreneurship Training Program [201810224067]
- Northeast Agricultural University Students' Innovation and Entrepreneurship Training Program
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Chlorothalonil (CHT) suffered from its poor water solubility, which limited the application of CHT and might cause environmental pollution due to the use of organic solvents. In our research, inclusion complexes of hydroxypropyl-beta-cyclodextrin (HP beta CD) and beta-cyclodextrin (beta-CD) with CHT were formed to investigate the effect of beta-CD and HP beta CD on the water solubility, antifungal activity and thermal stability of CHT. The structure and characteristics of the two inclusion complexes were systematically evaluated by nuclear magnetic resonance (H-1 NMR), scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR) and thermal gravity analysis (TGA). The results of H-1 NMR, FT-IR, SEM and XRD indicated that CHT successfully entered the cavity of beta-CD and HP beta CD. TGA results proved that the thermal stability of CHT was significantly improved. Molecular modelling demonstrated that cyclodextrin could effectively complex with CHT. In addition, the biological activity test showed that the complexes had better antifungal activity than original CHT. Our research can provide useful information for the more reasonable use of CHT, and cyclodextrin can be more used in agriculture to improve the characteristics of pesticides. (C) 2019 Elsevier B.V. All rights reserved.
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