Preparation and characterization of the pH and thermosensitive magnetic molecular imprinted nanoparticle polymer for the cancer drug delivery

A novel pH and thermosensitive magnetic nanoparticle polymer composite [poly(NIPAAM@Fe3O4 MNPs/TMSPMC/DOX)] was synthesized by radical polymerization of N-isopropylacrylamide (NIPAAM) and the methacrylate functionalized Fe3O4 nanoparticles/DOX complex using AIBN and EGDMA, and used as a drug carrier for the DOX drug delivery. Formation of poly(NIPAAM@Fe3O4 MNPs/TMSPMC/DOX) was confirmed by FTIR, XRD, UV-Vis, VSM, TGA-DTA and SEM. The results showed the high DOX loading controls release. Moreover, it showed the lower critical solution temperature of 40 degrees C which can be beneficial in cancer drug delivery, since the temperature of cancer cells is higher than normal ones, and DOX can be released selectively in cancer cells. (C) 2016 Elsevier Ltd. All rights reserved.