Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 26, Issue 15, Pages 3626-3628Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2016.06.004
Keywords
Trifluoromethylpyrazole; Chiral chain; Nematocidal activity; Synthesis; Docking
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Funding
- Zhejiang Provincial Science Foundation of China [LY16C140007]
- Research Institute Special Program of Department of Science and Technology of Zhejiang Province [2015F50030]
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A series of novel chiral fluorinated pyrazole carboxamides derivatives were designed and synthesized. All these title compounds were confirmed by NMR and MS. The primarily nematocidal activity results indicated that some of them exhibited good control efficacy against the tomato root-knot nematode disease caused by Meloidogyne incognita. The docking results indicated that compound 5n interact with amino acid residue Tyr 121, Trp 279 of AchE via hydrogen bond. (C) 2016 Elsevier Ltd. All rights reserved.
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