Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 62, Issue 21, Pages 9990-9995Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jmedchem.9b01254
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Funding
- NIH [R15GM124596]
- American Heart Association [18PRE34030099]
- USDA National Institute of Food and Agriculture (Hatch Capacity Grant) [UTA-01178]
- National Science Foundation [CHE-1429195]
- USU Office of Research (PDRF Fellowship)
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Carbon monoxide (CO) is a gasotransmitter produced in humans. An essential unanswered question in the design of carbon monoxide releasing molecules (CORMs) is whether the delivery molecule should be localized extra- or intracellularly to produce desired biological effects. Herein we show that extracellular CO release is less toxic and is sufficient to produce an anti-inflammatory effect similar to that of intracellular CO release at nanomolar concentrations. This information is valuable for the design of CORMs.
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