Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 26, Issue 19, Pages 4687-4691Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2016.08.052
Keywords
Croton laui; Labdane diterpenoid; Anti-inflammatory activity
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Funding
- Natural Science Foundations of China [81673319, 81202429, 81273390, 81473116]
- Natural Science Foundation of Guangdong Province [S2013020012864]
- 111 Project [B13038]
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Nine new labdane diterpenoids (1-9) were isolated from the aerial parts of Croton laui, along with eight known analogues (10-17). Their structures were identified on the basis of the spectral data (IR, UV, HRESIMS, 1D and 2D NMR), and the structure of 8 was confirmed by single crystal X-ray diffraction analyses. In addition, compounds 1, 4, 7, 8, and 14 showed weak anti-inflammatory activities in LPS-stimulated RAW 264.7 cells. (C) 2016 Published by Elsevier Ltd.
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