Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 26, Issue 4, Pages 1173-1176Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2016.01.044
Keywords
Scleroderma UFSMSc1 (Persoon) Fries; Fungal endophyte; Lanostenoids; Anticandidal activity
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Funding
- CNPq - Brazil (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)
- FAPERGS - Brazil (Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul) [PRONEX-10/0029-0]
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Two lanostane triterpenoids (sclerodols A and B) were isolated from the culture of the Eucalyptus grandis derived from the endophyte Scleroderma UFSM Sc1(Persoon) Fries together with three known compounds: one related triterpenoid lanosta-8,23-dien-3 beta,25-diol, the disaccharide alpha,beta-trehalose, and the sugar alcohol mannitol. Their structures were elucidated on the basis of 2D NMR, HRME, and single-crystal X-ray diffraction data. The methanol crude extract and the isolated lanostane triterpenoids showed promising anticandidal activities. (C) 2016 Published by Elsevier Ltd.
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