Journal
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
Volume 34, Issue 18, Pages 2985-2990Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14767058.2019.1676413
Keywords
Congenital heart disease; double aortic arch; fetus; incidence; pediatric; prenatal diagnosis; right aortic arch
Categories
Funding
- Fetal Medicine Foundation [U.K.] [1037116]
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The study found that the incidence of isolated right aortic arch (RAA) and double aortic arch (DAA) in fetuses undergoing routine first-trimester ultrasound examination in a local population is 2-3 times higher than that reported in postnatal studies. Additionally, the risk for these abnormalities is substantially increased in fetuses conceived by in vitro fertilization (IVF), with a significantly higher median maternal age in the group with isolated RAA or DAA.
Objective: To define the incidence of variants of aortic arch sidedness in fetuses undergoing routine first trimester ultrasound examination. Methods: The data for this study were derived from prospective routine ultrasound examination at 11(+0) to 13(+6) weeks? gestation in singleton pregnancies examined in a local population between January 2014 and March 2018. We examined the incidence of isolated right aortic arch (RAA) and double aortic arch (DAA) in the local, screened population and compared the groups with and without these abnormalities. Results: The study population of 33,202 pregnancies included 18 (5.4 per 10,000) cases with isolated RAA and 5 (1.5 per 10,000) with DAA. In the group with isolated RAA or DAA, compared to those without, the median maternal age was higher and the incidence of conceptions from in vitro fertilization (IVF) was eight-fold higher. The prevalence of 22q11microdeletion was 5% in patients with RAA from this local population. Conclusions: The incidence of isolated RAA and DAA in a local population undergoing routine first-trimester ultrasound examination is 2?3-fold higher than that reported in postnatal studies and the risk for these abnormalities is substantially increased in fetuses conceived by IVF.
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