Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 26, Issue 10, Pages 2438-2441Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2016.03.115
Keywords
Colpoma sp.; Henriettea tuberculosa; Diketopiperazines; Marfey's method
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Funding
- SEOK CHUN Research Fund, Sungkyunkwan University
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Three new diketopiperazines (1-3), cyclo(L-Pro-D-trans-Hyp) (1), cyclo(L-Pro-D-Glu) (2), and cyclo(D-Pro-D-Glu) (3) and five known diketopiperazines (4-8) were isolated from the endolichenic fungus Colpoma sp. CR1465A identified from the Costa Rican plant Henriettea tuberculosa (Melatomataceae). The structures of the new compounds 1-3 were elucidated using a combination of extensive spectroscopic analyses, including 2D NMR and HR-MS, and their absolute configurations were determined by a combination of NOESY analysis and Marfey's method. Cyclo(L-Pro-D-allo-Thr) (4) was recently isolated from a South China Sea marine sponge Callyspongia sp., but its NMR spectroscopic data were not reported, and cyclo(L-Pro-L-Asp) (5) was previously reported but only as a synthetic product. The NMR data assignments of compounds 4 and 5 are reported for the first time. All of the isolated compounds were tested for antifungal and antimicrobial properties. (C) 2016 Elsevier Ltd. All rights reserved.
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