Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 26, Issue 5, Pages 1495-1497Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2015.09.010
Keywords
Oxytropis ochrocephala; Poisonous plant; Antiproliferative; Sophoridine derivatives
Categories
Funding
- Special Scientific Research Fund of Agriculture Public Welfare Industry [201203062]
- Chinese National Natural Science Foundation [31360084]
- Natural Science Foundation of Guizhou Province [20102273]
- China Scholarship Council (CSC)
- NIH from the National Cancer Institute [CA177584]
- Teaching and Learning Excellence Program from Kaohsiung Medical University
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Ten alkaloids (1-10), with sophoridine (1) as the most abundant component, were obtained from the whole plants of Oxytropis ochrocephala Bunge. Furthermore, eight new sophoridine derivatives (11-16, 20, 21), with modification on the C-14 position of 1 were synthesized. All compounds (1-16, 20, 21) were evaluated for antiproliferative activity against five human tumor cell lines. Among them, the newly synthesized derivative 20 exhibited the best inhibitory activity against the tested cell lines. Its activity was increased by more than fourfold as compared with parent compound 1. (C) 2015 Elsevier Ltd. All rights reserved.
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