Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 26, Issue 19, Pages 4829-4831Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2016.08.020
Keywords
1,3,4-Oxadiazole; Nicotinohydrazide; Cyclization; Anticancer agents; Human cancer cell lines
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Funding
- Council of Scientific and Industrial Research (CSIR), New Delhi, India [CSC-0204]
- CSIR
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A series of novel nicotinohydrazide derivatives 6a-g and 1,3,4-oxadiazole functionalized pyridine derivatives 7a-k and 8a-d were prepared in series of steps. All the compounds were screened for cytotoxicity against HeLa (cervical), DU145 (prostate), HepG2 (liver) and MBA-MB-231 (breast) human cancer cell lines. Compounds 6h, 6i, 7d, 7h, 7i and 8b which showed promising cytotoxicity at < 15 mu M concentration have been identified. Further optimization of the structure is underway to identify a lead compound. (C) 2016 Elsevier Ltd. All rights reserved.
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