Journal
JOURNAL OF MAGNETIC RESONANCE
Volume 307, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jmr.2019.106577
Keywords
Hyperpolarization; SABRE; Co-ligands; High field; Pulse sequences
Funding
- NSF [CHE-1665090]
- National Institute of Biomedical Imaging and Bioengineering of the NIH [R21EB025313, R21EB026153]
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Signal Amplification By Reversible Exchange, or SABRE, uses the singlet-order of parahydrogen to generate hyperpolarized signals on target nuclei, bypassing the limitations of traditional magnetic resonance. Experiments performed directly in the magnet provide a route to generate large magnetizations continuously without having to field-cycle the sample. For heteronuclear SABRE, these high-field methods have been restricted to the few SABRE complexes that exhibit efficient exchange with symmetric ligand environments as co-ligands induce chemical shift differences between the parahydrogen-derived hydrides, destroying the hyperpolarized spin order. Through careful consideration of the underlying spin physics, we introduce H-1 decoupled LIGHT-SABRE pulse sequence variants which bypasses this limitation, drastically expanding the scope of heteronuclear SABRE at high field. (C) 2019 Elsevier Inc. All rights reserved.
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