Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 26, Issue 18, Pages 4523-4526Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2016.07.022
Keywords
Morita-Baylis-Hillman adducts; Homodimers; Twin drugs; Leishmania donovani
Categories
Funding
- CNPq - Brazil
- CAPES - Brazil
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It is reported here the synthesis of novel Homodimers 12-19 of Morita-Baylis-Hillman adducts (MBHA) from one-pot Morita-Baylis-Hillman Reaction (MBHR) between aromatic aldehydes as eletrophiles and ethylene glycol diacrylate as Michael acceptor (35-94% yields) using cheap and green conditions. The bioactivities were evaluated against promastigote form of Leishmania donovani. All homodimers showed to be more potent than corresponding monomers. It is worth highlighting that the halogenated homodimers 17 and 18 (0.50 mu M) is almost 400 times more active than the corresponding monomer 10 and 1.24 times more potent than the second-line drug amphotericin B (0.62 mu M). Moreover, the selectivity index to 18 is very high (SIrb > 400) far better than amphotericin B (SIrb = 18.73). This is the first report of twin drugs strategy applied on Morita-Baylis-Hillman adducts. (C) 2016 Elsevier Ltd. All rights reserved.
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