Journal
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
Volume 62, Issue 1, Pages 148-159Publisher
WILEY
DOI: 10.1111/jipb.12879
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Funding
- National Key Research and Development Program [2018YFD1000200]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB27040000]
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DNA methylation is a conserved and important epigenetic mark in both mammals and plants. DNA methylation can be dynamically established, maintained, and removed through different pathways. In plants, active DNA demethylation is initiated by the RELEASE OF SILENCING 1 (ROS1) family of bifunctional DNA glycosylases/lyases. Accumulating evidence suggests that DNA demethylation is important in many processes in plants. In this review, we summarize recent studies on the enzymes and regulatory factors that have been identified in the DNA demethylation pathway. We also review the functions of active DNA demethylation in plant development as well as biotic and abiotic stress responses. Finally, we highlight those aspects of DNA demethylation that require additional research.
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