Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 26, Issue 3, Pages 879-881Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2015.12.076
Keywords
Dinormonoterpenes; Sinularia mollis; Cytotoxicity; Antiviral activity; HCMV (human cytomegalovirus)
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Funding
- Ministry of Science and Technology [MOST 102-2320-B-110-003-MY3]
- NSYSUKMU Joint Project of Taiwan [NSYSUKMU 2013-P018]
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Two novel dinormonoterpenes, designated as mollisolactones A and B, were discovered from the soft coral Sinularia mollis on the basis of a chromatographic and NMR spectroscopy-based fractionation. Their structures were solved through analysis of comprehensive 1D and 2D NMR spectroscopic data and HRESIMS experiments. The biological activities of the obtained metabolites were evaluated for cytotoxicity against A-459 (human lung carcinoma), HT-29 (human colon adenocarcinoma), and P-388 (mouse lymphocytic leukemia) cancer cell lines as well as antiviral activity against HCMV (human cytomegalovirus). (C) 2015 Elsevier Ltd. All rights reserved.
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