Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 220, Issue -, Pages S190-S197Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiz272
Keywords
African meningitis belt; Neisseria meningitidis; outbreak; serogroup C; sequence type
Categories
Funding
- MenAfriNet consortium
- Bill & Melinda Gates Foundation [OPP1084298]
- Bill and Melinda Gates Foundation [OPP1084298] Funding Source: Bill and Melinda Gates Foundation
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In 2016, Mali reported a bacterial meningitis outbreak consisting of 39 suspected cases between epidemiologic weeks 9 and 17 with 15% case fatality ratio in the health district of Ouelessebougou, 80 kilometers from the capital Bamako. Cerebrospinal fluid specimens from 29 cases were tested by culture and real-time polymerase chain reaction; 22 (76%) were positive for bacterial meningitis pathogens, 16 (73%) of which were Neisseria meningitidis (Nm). Of the Nm-positive specimens, 14 (88%) were N meningitidis serogroup C (NmC), 1 was NmW, and 1 was nongroupable. Eight NmC isolates recovered by culture from the outbreak were characterized using whole genome sequencing. Genomics analysis revealed that all 8 isolates belonged to a new sequence type (ST) 12446 of clonal complex 10217 that formed a distinct clade genetically similar to ST-10217, a NmC strain that recently caused large epidemics of meningitis in Niger and Nigeria. The emergence of a new ST of NmC associated with an outbreak in the African meningitis belt further highlights the need for continued molecular surveillance in the region.
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