Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 26, Issue 2, Pages 622-625Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2015.11.064
Keywords
Nucleic acid-based therapeutics; Prodrug; Protecting group; Glutathione
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology, Japan
- Takahashi Industrial and Economic Research Foundation
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We have examined substituted benzyl protecting groups for the phosphodiester in oligodeoxyribonucleotides. Stability of the protecting groups in buffer and rates of deprotection by glutathione (GSH) were strongly influenced by benzyl ring substituents. (C) 2015 Elsevier Ltd. All rights reserved.
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