Journal
JOURNAL OF HEMATOLOGY & ONCOLOGY
Volume 12, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s13045-019-0797-3
Keywords
Myeloid-derived suppressor cells; Hematological malignancies; Lymphoma; Multiple myeloma; Leukemia; Hematopoietic stem cell transplantation
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Funding
- National Key Research and Development Plan of China [2017YFA0104500]
- Foundation for Innovative Research Groups of the National Natural Science Foundation of China [81621001]
- National Natural Science Foundation of China [81530046, 81873445, 81930004]
- Science and Technology Project of Guangdong Province of China [2016B030230003]
- Peking University Clinical Scientist Program [BMU2019LCKXJ003]
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Myeloid-derived suppressor cells (MDSCs) are newly identified immature myeloid cells that are characterized by the ability to suppress immune responses and expand during cancer, infection, and inflammatory diseases. Although MDSCs have attracted a lot of attention in the field of tumor immunology in recent years, little is known about their multiple roles in hematological malignancies as opposed to their roles in solid tumors. This review will help researchers better understand the various characteristics and functions of MDSCs, as well as the potential therapeutic applications of MDSCs in hematological malignancies, including lymphoma, multiple myeloma, leukemia, and hematopoietic stem cell transplantation.
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