Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 26, Issue 1, Pages 194-196Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2015.11.003
Keywords
Triplex forming oligonucleotide; Base pair recognition; C-5 modified nucleoside; Hybridization ability; Antigene method
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Funding
- JSPS KAKENHI [26288075]
- Grants-in-Aid for Scientific Research [26288075] Funding Source: KAKEN
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5-[3-(2-Aminopyrimidin-4-yl)aminopropyn-1-yl]uracil (UraPyr) was designed as a new nucleobase to recognize Ade-Thy base pair in double-stranded DNA. We successfully synthesized the dexoynucleoside phosphoramidite having UraPyr and incorporated it into triplex forming oligonucleotides (TFOs). Melting temperature analysis revealed that introduction of UraPyr into TFOs could effectively stabilize their triplex structures without loss of base recognition capabilities. (C) 2015 Elsevier Ltd. All rights reserved.
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