Journal
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
Volume 33, Issue 5, Pages 256-264Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0891988719882104
Keywords
health-related quality of life; somatic comorbidities; cognitive functioning; neuropsychiatric symptoms; subjective cognitive decline; mild cognitive impairment
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Funding
- Alzheimer Nederland [20083494]
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Objective: To identify determinants within 3 different domains (ie, somatic comorbidities, cognitive functioning, and neuropsychiatric symptoms [NPS]) of health-related quality of life (HRQoL) over time in memory clinic patients without dementia. Methods: This longitudinal multicenter cohort study with a 3-year observation period recruited 315 individuals (age: 69.8 +/- 8.6, 64.4% males, Mini-Mental State Examination score 26.9 +/- 2.6). A multivariable explanatory model was built using linear mixed effects models (forward selection per domain) to select determinants for self-perceived HRQoL over time, as measured by the EuroQoL-5D visual analogue scale (EQ VAS). Results: Mean HRQoL at study entry was 69.4 +/- 15.6. The presence of agitation, appetite and eating abnormalities, and eyes/ears/nose (ie, sensory impairment) comorbidities were associated with a change in HRQoL over time. Agitation was most strongly associated with HRQoL over time. Conclusions: The association of somatic comorbidities and NPS in memory clinic patients with course of HRQoL shows that these should receive more awareness, detection, and monitoring by clinicians.
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