Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 26, Issue 16, Pages 4042-4051Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2016.06.079
Keywords
Ischemia/reperfusion injury; Curcumin analogues; Anti-inflammatory activity; Free radical scavenging activity; Thrombolytic activity
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Funding
- NIH [GM088795-01]
- NSF [1048655]
- NASA [MSGC R85197]
- MIIE [1204010]
- VPR-SI fund [R01386]
- Research Excellence Fund [R01121, R01323]
- SURF fund
- National Science Foundation of China [81370419]
- Natural Science Foundation of HeBei, China [062761266]
- Administration of Traditional Chinese Medicine of HeBei Province [2007134]
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We describe several novel curcumin analogues that possess both anti-inflammatory antioxidant properties and thrombolytic activities. The therapeutic efficacy of these curcumin analogues was verified in a mouse ear edema model, a rat arterial thrombosis assay, a free radical scavenging assay performed in PC12 cells, and in both in vitro and in vivo ischemia/reperfusion models. Our findings suggest that their protective effects partially reside in maintenance of optimal mitochondrial function. Published by Elsevier Ltd.
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