Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 26, Issue 15, Pages 3780-3784Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2016.05.048
Keywords
Tacca vietnamensis; Taccaceae; Steroidal saponin; Anti-inflammation
Categories
Funding
- Vietnam National Foundation for Science and Technology Development (NAFOSTED) [104.01-2012.22]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [NRF-2011-0025129]
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Using various chromatographic methods, five new steroidal saponins named taccavietnamosides A-E (1-5) and three known, (24S,25R)-spirost-5-en-3 beta,24-diol 3-O-alpha-L-rhamnopyranosyl-(1 -> 2)-[alpha-L-rhamnopyranosyl-(1 -> 3)]-beta-D-glucopyranoside (6), (24S, 25R)-spirost-5-en-3b, 24-diol 3-O-alpha-Lrhamnopyranosyl-(1 -> 2)-[beta-D-glucopyranosyl-(1 -> 4)-alpha-L-rhamnopyranosyl-(1 -> 3)]-beta-D-glucopyranoside (7), and chantrieroside A(8) were isolated from the rhizomes of Tacca vietnamensis Thin et Hoat. Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for the inhibitory activities of nitric oxide production in LPS-stimulated RAW 264.7 macrophages and BV2 cells. As the results, compounds 3-5 showed moderate inhibition on NO production in LPS-stimulated BV2 cells and RAW 264.7 macrophages with the IC50 values ranging from 37.0 to 60.7 mu M. (C) 2016 Elsevier Ltd. All rights reserved.
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