4.5 Article

Anionic fluoroquinolones as antibacterials against biofilm-producing Pseudomonas aeruginosa

Journal

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 26, Issue 4, Pages 1305-1309

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2016.01.012

Keywords

Fluoroquinolone; Pseudomonas; Mucoid; Biofilm; Antibacterial

Funding

  1. Marshall University School of Pharmacy FRS Grant Program
  2. Office of Experiential Learning
  3. National Institutes of Health (NIH) [UL1TR000117]
  4. NIH [P20GM103434]

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Pseudomonas aeruginosa is a common biofilm-forming bacterial pathogen implicated in diseases of the lungs. The extracellular polymeric substances (EPS) of respiratory Pseudomonas biofilms are largely comprised of anionic molecules such as rhamnolipids and alginate that promote a mucoid phenotype. In this Letter, we examine the ability of negatively-charged fluoroquinolones to transverse the EPS and inhibit the growth of mucoid P. aeruginosa. Anionic fluoroquinolones were further compared with standard antibiotics via a novel microdiffusion assay to evaluate drug penetration through pseudomonal alginate and respiratory mucus from a patient with cystic fibrosis. (C) 2016 Elsevier Ltd. All rights reserved.

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