Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 26, Issue 19, Pages 4565-4567Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2016.08.086
Keywords
Fullerene; Hepatitis C virus (HCV); NS3/4A protease; NS5B polymerase
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Funding
- Health Labor Sciences Research Grant from the Ministry of Health, Labor, and Welfare of Japan (MHLW)
- Platform for Drug Discovery, Informatics, and Structural Life Science from the Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT)
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We evaluated the Hepatitis C virus (HCV) NS5B polymerase and HCV NS3/4A protease inhibition activities of a new set of proline-type fullerene derivatives. All of the compounds had the potential to inhibit both the enzymes, indicating that the fullerene derivatives may be dual inhibitors against NS5B and NS3/4A and could be novel lead compounds for the treatment of HCV infections. (C) 2016 Elsevier Ltd. All rights reserved.
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