Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 24, Issue 3, Pages 354-361Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2015.07.064
Keywords
Crop protection; Disease control; Oomycete fungicide; Oxysterol binding protein; Oxathiapiprolin
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Oxathiapiprolin is the first member of a new class of piperidinyl thiazole isoxazoline fungicides with exceptional activity against plant diseases caused by oomycete pathogens. It acts via inhibition of a novel fungal target-an oxysterol binding protein-resulting in excellent preventative, curative and residual efficacy against key diseases of grapes, potatoes and vegetables. Oxathiapiprolin is being developed globally as DuPont (TM) Zorvec (TM) disease control with first registration and sales anticipated in 2015. The discovery, synthesis, optimization and biological efficacy are presented. (C) 2015 Elsevier Ltd. All rights reserved.
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