Journal
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
Volume 856, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jelechem.2019.113592
Keywords
Ionothermal reaction; Metal-organic framework; AuNPs-NH2/Cu-MOF/GCE; Hydrogen peroxide
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Funding
- National Natural Science Foundation of China [51672167]
- Natural Science Foundation of Shaanxi Province [2018JM2042]
- Fundamental Research Funds for the Central Universities [GK201803030]
- Science and Technology program of Xi' an [201805027YD5CG11 (3)]
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Hydrogen peroxide (H2O2) plays an important role in physiological processes. In this work, a Cu-based metal-organic framework (Cu-MOF) was synthesized under ionothermal condition, further grafted with ammoniated Au nanoparticles (AuNPs-NH2) to prepare AuNPs-NH2/Cu-MOF composite. Glassy carbon electrode (GCE) was modified with AuNPs-NH2/Cu-MOF to prepare AuNPs-NH2/Cu-MOF/GCE electrode, which was used in H2O2 detection. AuNPs-NH2/Cu-MOF/GCE exhibits itself as a highly sensitive and selective electrochemical enzyme-free sensor for H2O2 detection. A quantitative detection to H2O2 can be found with a wide linear response toward H2O2 concentrations ranging 5-850 mu M, its limit of detection (LOD) is as low as 1.2 mu M with a high sensitivity of 1.71 mu A/cm(2).mu M. AuNPs-NH2/Cu-MOF/GCE sensor has been applied to determine H2O2 effectively in human cervical cancer cells by adding the ascorbic acid as the stimulant. Our work presented a AuNPs-NH2/Cu-MOF/GCE composite electrode which is a promising enzyme-free electrochemical sensor for quantitive H2O2 detection in human cervical cancer cells.
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