Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 24, Issue 5, Pages 1132-1135Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2016.01.044
Keywords
Glycopeptides; Nanoparticles; Vaccines; Antibodies; Cancer
Funding
- Alexander von Humboldt Fellowship
- Research Center for Immunotherapy (FZI) of the University Medical Center of JGU Mainz [SFB 1066]
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We report the preparation of gold nanoparticle (AuNP)-based vaccine candidates against the tumor-associated form of the mucin-1 (MUC1) glycoprotein. Chimeric peptides, consisting of a glycopeptide sequence derived from MUC1 and the T-cell epitope P30 sequence were immobilized on PEGylated AuNPs and the ability to induce selective antibodies in vivo was investigated. After immunization, mice showed significant MHC-II mediated immune responses and their antisera recognized human MCF-7 breast cancer cells. Nanoparticles designed according to this report may become key players in the development of anticancer vaccines. (C) 2016 Elsevier Ltd. All rights reserved.
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