Journal
JOURNAL OF CLUSTER SCIENCE
Volume 31, Issue 5, Pages 1003-1011Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10876-019-01705-6
Keywords
Lactobacillus acidophilus; Selenium nanoparticles; Biocompatible; Biofilm; Antioxidant
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Funding
- Indian Council of Medical Research, Govt. of India [35/8/2012-BMS]
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In the present study, nontoxic selenium nanoparticles were synthesized extracellularly using probiotic bacteria Lactobacillus acidophilus. The synthesized Lactobacillus acidophilus mediated selenium nanoparticles (LA-SeNPs) show the surface plasmon resonance (SPR) at 385 nm. The hydrodynamic radius of LA-SeNPs was found to be 34.13 nm along with polydispersity index (0.28) and zeta potential (+ 37.86 mV). TEM shows that the average diameter of LA-SeNPs is 2-15 nm. FTIR suggest that extracellular proteins present in bacterial culture were responsible for reduction and stabilization of Se ions to LA-SeNPs. The antibacterial activity of synthesized nanoparticles was studied against five different sensitive and resistant bacterial strains. The MIC90 for bacterial strains were in the range +/- 1 to +/- 10 mu g/ml. The inhibition and degradation of bacterial biofilm were studied against all the tested strains. The synthesized nanoparticles were cyto-compatible against human HEK-293 normal cell lines shown by MTT assay.
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