Journal
JOURNAL OF CELL SCIENCE
Volume 132, Issue 20, Pages -Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.235085
Keywords
Immune response; Intercellular communication; Microvesicles
Categories
Funding
- National Institutes of Health
- Catherine Peachey Fund
- 100 Voices of Hope
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Extracellular vesicles (EVs) are a heterogeneous collection of membrane-bound vesicles released by cells that contain bioactive cargoes including proteins, lipids and nucleic acids. Multiple subpopulations of EVs have now been recognized and these include exosomes and microvesicles. EVs have been thought to facilitate intercellular and distal communication to bring about various processes that enable tumor progression and metastases. Here, we describe the current knowledge of the functional cargo contained within EVs, with a focus on tumor microvesicles, and review the emerging theory of how EVs support immune suppression in cancer.
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