Journal
JOURNAL OF BIOCHEMISTRY
Volume 167, Issue 1, Pages 41-48Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jb/mvz079
Keywords
breast cancer; Hsa-miR-146a; invasion; NM23-H1; proliferation
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The study aimed to investigate the regulatory effect of miR-146a in proliferation, invasion and migration of breast cancer and its possible mechanism via NM23-H1. The expression levels of miR-146a in breast cancer with different pathological classification were significantly increased, while the expression levels of NM23-H1 were significantly decreased, which were closely correlated. Double luciferase reporter gene was used to verify the target regulatory relationship between miR-146 and NM23-H1 on a human breast cancer cell line. miR-146a was closely related to the proliferation and metastasis of breast cancer. miR-146a also promoted the growth of breast cancer in vivo via targeting NM23-H1. In conclusion, miR-146 can promote the proliferation and invasion of breast cancer by targeting NM23-H1.
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